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Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor
More than 80% of colorectal cancer patients have adenomatous polyposis coli (APC) mutations, which induce abnormal WNT/β-catenin activation. Tankyrase (TNKS) mediates the release of active β-catenin, which occurs regardless of the ligand that translocates into the nucleus by AXIN degradation via the...
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| Pubblicato in: | Int J Mol Sci |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8303674/ https://ncbi.nlm.nih.gov/pubmed/34298950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147330 |
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