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Discovery of Oxazol-2-amine Derivatives as Potent Novel FLT3 Inhibitors
Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) is the most common mutation in patients with acute myeloid leukemia (AML). FLT3-ITD(+) induces constitutive activation of FLT3, causing an abnormally rapid proliferation of cancer cells. In this study, we identified novel FLT3 in...
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| Publicado en: | Molecules |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7663913/ https://ncbi.nlm.nih.gov/pubmed/33167505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25215154 |
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