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Discovery of LDD-1075 as a potent FLT3 inhibitor
Fms-like tyrosine kinase 3 (FLT3) is a valuable pharmacological target in the treatment of acute myeloid leukemia (AML). LDD-1075 and LDD-1076 are indirubin derivatives, and LDD-1075 is the ester form of LDD-1076. LDD-1076 exhibited a potent in vitro FLT3 kinase activity inhibition with an IC(50) of...
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| Publicado no: | Oncol Lett |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
D.A. Spandidos
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6444428/ https://ncbi.nlm.nih.gov/pubmed/30944659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.10096 |
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