Discovery of a FLT3 inhibitor LDD1937 as an anti-leukemic agent for acute myeloid leukemia

FMS-like receptor tyrosine kinase-3 (FLT3) belongs to the family of receptor tyrosine kinase (RTK), and the FLT3 mutation is observed in 1/3 of all acute myeloid leukemia (AML) patients. Potential FLT3 inhibitors have been investigated as potential therapeutic agents of AML. In this study, we identi...

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Pubblicato in:Oncotarget
Autori principali: Lee, Hyo Jeong, Lee, Jungeun, Jeong, Pyeonghwa, Choi, Jungil, Baek, Juhwa, Ahn, Su Jin, Moon, Yeongyu, Heo, Jeong Doo, Choi, Young Hee, Chin, Young-Won, Kim, Yong-Chul, Han, Sun-Young
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787524/
https://ncbi.nlm.nih.gov/pubmed/29416667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23221
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