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A multi-step nucleation process determines the kinetics of prion-like domain phase separation

Compartmentalization by liquid-liquid phase separation (LLPS) has emerged as a ubiquitous mechanism underlying the organization of biomolecules in space and time. Here, we combine rapid-mixing time-resolved small-angle X-ray scattering (SAXS) approaches to characterize the assembly kinetics of a pro...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Martin, Erik W., Harmon, Tyler S., Hopkins, Jesse B., Chakravarthy, Srinivas, Incicco, J. Jeremías, Schuck, Peter, Soranno, Andrea, Mittag, Tanja
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302766/
https://ncbi.nlm.nih.gov/pubmed/34301955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24727-z
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