RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors

In animal germlines, PIWI proteins and the associated PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposons. Here we report the extensive sequence and quantitative correlations between 2′,3′-cyclic phosphate-containing RNAs (cP-RNAs), identified using cP-RNA-seq, and piRNA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Shigematsu, Megumi, Kawamura, Takuya, Morichika, Keisuke, Izumi, Natsuko, Kiuchi, Takashi, Honda, Shozo, Pliatsika, Venetia, Matsubara, Ryuma, Rigoutsos, Isidore, Katsuma, Susumu, Tomari, Yukihide, Kirino, Yohei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302750/
https://ncbi.nlm.nih.gov/pubmed/34301931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24681-w
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