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Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
Expressed on cells of the myeloid and lymphoid lineages, V-domain Ig Suppressor of T cell Activation (VISTA) is an emerging target for cancer immunotherapy. Blocking VISTA activates both innate and adaptive immunity to eradicate tumors in mice. Using a tripeptide small molecule antagonist of VISTA C...
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| Publicat a: | Commun Biol |
|---|---|
| Autors principals: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8302676/ https://ncbi.nlm.nih.gov/pubmed/34302042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02381-x |
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