Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator

BACKGROUND: No effective approaches to target mutant Kras have yet been developed. Immunoprevention using KRAS-specific antigenic peptides to trigger T cells capable of targeting tumor cells relies heavily on lipid metabolism. To facilitate better TCR/peptide/MHC interactions that result in better c...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Pan, Jing, Zhang, Qi, Palen, Katie, Wang, Li, Qiao, Lifen, Johnson, Bryon, Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, You, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945201/
https://ncbi.nlm.nih.gov/pubmed/31680003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.044
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