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Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro
3-Bromopyruvate (3-BrPA) is an alkylating agent and a well-known inhibitor of energy metabolism. Rapamycin is an inhibitor of the Serine/Threonine protein kinase “mammalian target of rapamycin (mTOR). Both 3-BrPA and rapamycin show chemopreventive efficacy in mouse models of lung cancer. Aerosol del...
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| Publicado no: | Cancer Prev Res (Phila) |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6004825/ https://ncbi.nlm.nih.gov/pubmed/25644152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0142 |
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