Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Activation of Pannexin 1 (PANX1) ion channels causes release of intercellular signaling molecules in a variety of (patho)physiological contexts. PANX1 can be activated by G protein-coupled receptors (GPCRs), including α1-adrenergic receptors (α1-ARs), but how receptor engagement leads to channel ope...

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Publicat a:Nat Commun
Autors principals: Chiu, Yu-Hsin, Medina, Christopher B., Doyle, Catherine A., Zhou, Ming, Narahari, Adishesh K., Sandilos, Joanna K., Gonye, Elizabeth C., Gao, Hong-Yu, Guo, Shih Yi, Parlak, Mahmut, Lorenz, Ulrike M., Conrads, Thomas P., Desai, Bimal N., Ravichandran, Kodi S., Bayliss, Douglas A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302610/
https://ncbi.nlm.nih.gov/pubmed/34301959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24825-y
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