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Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) repeats of collagen; however, the exact binding sites...
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| Publicat a: | Biomolecules |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8301893/ https://ncbi.nlm.nih.gov/pubmed/34356607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11070983 |
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