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Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors
HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) repeats of collagen; however, the exact binding sites...
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| 發表在: | Biomolecules |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8301893/ https://ncbi.nlm.nih.gov/pubmed/34356607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11070983 |
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