Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors

HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) repeats of collagen; however, the exact binding sites...

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Detaylı Bibliyografya
Yayımlandı:Biomolecules
Asıl Yazarlar: Cai, Haiyan, Sasikumar, Parvathy, Little, Gemma, Bihan, Dominique, Hamaia, Samir W., Zhou, Aiwu, Gibbins, Jonathan M., Farndale, Richard W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301893/
https://ncbi.nlm.nih.gov/pubmed/34356607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11070983
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