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Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments
Over a decade of genome-wide association studies (GWAS) have led to the finding of extreme polygenicity of complex traits. The phenomenon that “all genes affect every complex trait” complicates Mendelian Randomization (MR) studies, where natural genetic variations are used as instruments to infer th...
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| Gepubliceerd in: | PLoS Genet |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8301661/ https://ncbi.nlm.nih.gov/pubmed/34157017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009575 |
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