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New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities

Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among the compounds synthesized, compounds 1–3 showed greater inhibitory activity than kojic acid (IC(50) = 18.27 ± 0.89 μM); IC(50) = 3.70...

詳細記述

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書誌詳細
出版年:Antioxidants (Basel)
主要な著者: Jung, Hee Jin, Choi, Dong Chan, Noh, Sang Gyun, Choi, Heejeong, Choi, Inkyu, Ryu, Il Young, Chung, Hae Young, Moon, Hyung Ryong
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301170/
https://ncbi.nlm.nih.gov/pubmed/34356311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10071078
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