A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities. Of these eight compounds, (E)-3-(2,4-dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one (1c) showed strong competitive inhibit...

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Publicado no:Molecules
Main Authors: Kim, Chang Seok, Noh, Sang Gyun, Park, Yujin, Kang, Dongwan, Chun, Pusoon, Chung, Hae Young, Jung, Hee Jin, Moon, Hyung Ryong
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222382/
https://ncbi.nlm.nih.gov/pubmed/30360412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102725
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