TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

BACKGROUND: Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans. Increased levels of tumor necrosis factor-α (TNF-α) and transformi...

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Detalles Bibliográficos
Publicado en:BMC Musculoskelet Disord
Autores principales: Yokozeki, Yuji, Uchida, Kentaro, Kawakubo, Ayumu, Nakawaki, Mitsufumi, Okubo, Tadashi, Miyagi, Masayuki, Inoue, Gen, Itakura, Makoto, Sekiguchi, Hiroyuki, Takaso, Masashi
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299674/
https://ncbi.nlm.nih.gov/pubmed/34301215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-021-04509-w
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