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Enantioselective Ruthenium-BINAP-Catalyzed Carbonyl Reductive Coupling of Alkoxyallenes: Convergent Construction of syn-sec,tert-Diols via (Z)-σ-Allylmetal Intermediates

The first catalytic enantioselective ruthenium-catalyzed carbonyl reductive couplings of allene pronucleophiles is described. Using an iodide-modified ruthenium-BINAP-catalyst and O-benzhydryl alkoxyallene 1a, carbonyl (α-alkoxy)allylation occurs from the alcohol or aldehyde oxidation level to form...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Xiang, Ming, Pfaffinger, Dana E., Ortiz, Eliezer, Brito, Gilmar A., Krische, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299538/
https://ncbi.nlm.nih.gov/pubmed/34060818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c03480
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