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Diastereo- and Enantioselective Ruthenium-Catalyzed C-C Coupling of 1-Arylpropynes and Alcohols: Alkynes as Chiral Allylmetal Precursors in Carbonyl anti-(α-Aryl)allylation

Highly tractable 1-aryl-1-propynes, which are readily accessible via Sonogashira coupling, serve as chiral allylmetal pronucleophiles in ruthenium-JOSIPHOS-catalyzed anti-diastereo- and enantioselective aldehyde (α-aryl)allylations with primary aliphatic or benzylic alcohol proelectrophiles. This me...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Xiang, Ming, Ghosh, Ankan, Krische, Michael J.
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284912/
https://ncbi.nlm.nih.gov/pubmed/33555867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c12242
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