Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients

INTRODUCTION: Eicosanoids and intracellular signaling pathways are potential targets for host-directed therapy (HDT) in tuberculosis (TB). We have explored the effect of cyclooxygenase 2 inhibitor (COX-2i) treatment on eicosanoid levels and signaling pathways in monocytes. METHODS: Peripheral blood...

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Vydáno v:Front Cell Infect Microbiol
Hlavní autoři: Jøntvedt Jørgensen, Marthe, Nore, Kristin G., Aass, Hans Christian D., Layre, Emilie, Nigou, Jérôme, Mortensen, Rasmus, Tasken, Kjetil, Kvale, Dag, Jenum, Synne, Tonby, Kristian, Dyrhol-Riise, Anne Ma
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Cellular and Infection Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299478/
https://ncbi.nlm.nih.gov/pubmed/34307194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2021.669623
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