Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children’s Oncology Group

IMPORTANCE: Brain tumors are the leading cause of disease-related death in children. Medulloblastoma is the most common malignant embryonal brain tumor, and strategies to increase survival are needed. OBJECTIVE: To evaluate therapy intensification with carboplatin as a radiosensitizer and isotretino...

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Vydáno v:JAMA Oncol
Hlavní autoři: Leary, Sarah E. S., Packer, Roger J., Li, Yimei, Billups, Catherine A., Smith, Kyle S., Jaju, Alok, Heier, Linda, Burger, Peter, Walsh, Karin, Han, Yuanyuan, Embry, Leanne, Hadley, Jennifer, Kumar, Rahul, Michalski, Jeff, Hwang, Eugene, Gajjar, Amar, Pollack, Ian F., Fouladi, Maryam, Northcott, Paul A., Olson, James M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2021
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299367/
https://ncbi.nlm.nih.gov/pubmed/34292305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2021.2224
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