Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod

Alzheimer's disease (AD) induces time-dependent changes in sphingolipid metabolism, which may affect transcription regulation and neuronal phenotype. We, therefore, analyzed the influence of age, amyloid β precursor protein (AβPP), and the clinically approved, bioavailable sphingosine-1-phospha...

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Bibliografiske detaljer
Udgivet i:Front Mol Neurosci
Main Authors: Jęśko, Henryk, Wieczorek, Iga, Wencel, Przemysław Leonard, Gąssowska-Dobrowolska, Magdalena, Lukiw, Walter J., Strosznajder, Robert Piotr
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Molecular Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299068/
https://ncbi.nlm.nih.gov/pubmed/34305524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.660104
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