CD8(+) tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but the cellular and molecular mechanisms underlying NASH resolution remain unclarified. Here, using a murine diet...

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Pubblicato in:Nat Commun
Autori principali: Koda, Yuzo, Teratani, Toshiaki, Chu, Po-Sung, Hagihara, Yuya, Mikami, Yohei, Harada, Yosuke, Tsujikawa, Hanako, Miyamoto, Kentaro, Suzuki, Takahiro, Taniki, Nobuhito, Sujino, Tomohisa, Sakamoto, Michiie, Kanai, Takanori, Nakamoto, Nobuhiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298513/
https://ncbi.nlm.nih.gov/pubmed/34294714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24734-0
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