Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

BACKGROUND: We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-HCV and anticancer effects was explored. METHODS: The anti-HCV effect of brusat...

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Publicado en:BMC Cancer
Autores principales: Murakami, Yuko, Sugiyama, Kazuo, Ebinuma, Hirotoshi, Nakamoto, Nobuhiro, Ojiro, Keisuke, Chu, Po-sung, Taniki, Nobuhito, Saito, Yoshimasa, Teratani, Toshiaki, Koda, Yuzo, Suzuki, Takahiro, Saito, Kyoko, Fukasawa, Masayoshi, Ikeda, Masanori, Kato, Nobuyuki, Kanai, Takanori, Saito, Hidetsugu
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019801/
https://ncbi.nlm.nih.gov/pubmed/29940898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4588-y
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