C9orf72 deficiency promotes microglial mediated synaptic loss in aging and amyloid accumulation

C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to ALS/FTD, C9orf72 repeat expansions have been reported...

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Yayımlandı:Neuron
Asıl Yazarlar: Lall, Deepti, Lorenzini, Ileana, Mota, Thomas A., Bell, Shaughn, Mahan, Thomas E., Ulrich, Jason D., Davtyan, Hayk, Rexach, Jessica E., Muhammad, A.K.M. Ghulam, Shelest, Oksana, Landeros, Jesse, Vazquez, Michael, Kim, Junwon, Ghaffari, Layla, O’Rourke, Jacqueline Gire, Geschwind, Daniel H., Blurton-Jones, Mathew, Holtzman, David M., Sattler, Rita, Baloh, Robert H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298293/
https://ncbi.nlm.nih.gov/pubmed/34133945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2021.05.020
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