C9orf72 deficiency promotes microglial mediated synaptic loss in aging and amyloid accumulation

C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to ALS/FTD, C9orf72 repeat expansions have been reported...

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Publicado no:Neuron
Main Authors: Lall, Deepti, Lorenzini, Ileana, Mota, Thomas A., Bell, Shaughn, Mahan, Thomas E., Ulrich, Jason D., Davtyan, Hayk, Rexach, Jessica E., Muhammad, A.K.M. Ghulam, Shelest, Oksana, Landeros, Jesse, Vazquez, Michael, Kim, Junwon, Ghaffari, Layla, O’Rourke, Jacqueline Gire, Geschwind, Daniel H., Blurton-Jones, Mathew, Holtzman, David M., Sattler, Rita, Baloh, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8298293/
https://ncbi.nlm.nih.gov/pubmed/34133945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2021.05.020
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