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The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model
People with Down syndrome (DS), caused by trisomy of chromosome 21 have a greatly increased risk of developing Alzheimer’s disease (AD). This is in part because of triplication of a chromosome 21 gene, APP. This gene encodes amyloid precursor protein, which is cleaved to form amyloid-β that accumula...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8297773/ https://ncbi.nlm.nih.gov/pubmed/34292972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242236 |
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