Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer’s disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark amyloid plaques and neurofibrillary tangles of Alzheimer’s di...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Brain
Auteurs principaux: Wiseman, Frances K, Pulford, Laura J, Barkus, Chris, Liao, Fan, Portelius, Erik, Webb, Robin, Chávez-Gutiérrez, Lucia, Cleverley, Karen, Noy, Sue, Sheppard, Olivia, Collins, Toby, Powell, Caroline, Sarell, Claire J, Rickman, Matthew, Choong, Xun, Tosh, Justin L, Siganporia, Carlos, Whittaker, Heather T, Stewart, Floy, Szaruga, Maria, Murphy, Michael P, Blennow, Kaj, de Strooper, Bart, Zetterberg, Henrik, Bannerman, David, Holtzman, David M, Tybulewicz, Victor L J, Fisher, Elizabeth M C
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6061702/
https://ncbi.nlm.nih.gov/pubmed/29945247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy159
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires