Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (amyloid precursor protein) and the extra copy or ‘dose’ of APP...

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Published in:Sci Rep
Main Authors: Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952899/
https://ncbi.nlm.nih.gov/pubmed/33707583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85062-3
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