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Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models
Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (amyloid precursor protein) and the extra copy or ‘dose’ of APP...
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| Publicat a: | Sci Rep |
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| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7952899/ https://ncbi.nlm.nih.gov/pubmed/33707583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85062-3 |
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