Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation. Triclabendazole is a new type of imidazole in fluke resistance and has been approved by the FDA for the treatment...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yan, Liang, Liu, Yi, Ma, Xue-feng, Hou, Dan, Zhang, Yu-hui, Sun, Yong, Shi, Shan-shan, Forouzanfar, Tim, Lin, Hai-yan, Fan, Jun, Wu, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8297466/
https://ncbi.nlm.nih.gov/pubmed/34305590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.670081
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