A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemness activity. However, OphA, a fungus-derived natu...

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Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Okutachi, Sunday, Manoharan, Ganesh Babu, Kiriazis, Alexandros, Laurini, Christina, Catillon, Marie, McCormick, Frank, Yli-Kauhaluoma, Jari, Abankwa, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8296985/
https://ncbi.nlm.nih.gov/pubmed/34307350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.665673
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