PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

[Image: see text] The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and therefore activity. However, the...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Siddiqui, Farid A., Alam, Catharina, Rosenqvist, Petja, Ora, Mikko, Sabt, Ahmed, Manoharan, Ganesh babu, Bindu, Lakshman, Okutachi, Sunday, Catillon, Marie, Taylor, Troy, Abdelhafez, Omaima M., Lönnberg, Harri, Stephen, Andrew G., Papageorgiou, Anastassios C., Virta, Pasi, Abankwa, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964506/
https://ncbi.nlm.nih.gov/pubmed/31956834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03639
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