CYP3A4(∗)22 Genotyping in Clinical Practice: Ready for Implementation?

Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs. Therefore, genetic variation in CYP3A4 could potentially affect the pharmacokinetics, toxicity and clinical outcome of drug treat...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Mulder, Tessa A. M., van Eerden, Ruben A. G., de With, Mirjam, Elens, Laure, Hesselink, Dennis A., Matic, Maja, Bins, Sander, Mathijssen, Ron H. J., van Schaik, Ron H. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8296839/
https://ncbi.nlm.nih.gov/pubmed/34306041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.711943
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