Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation

Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Par...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Woillard, Jean-Baptiste, Mourad, Michel, Neely, Michael, Capron, Arnaud, van Schaik, Ron H., van Gelder, Teun, Lloberas, Nuria, Hesselink, Dennis A., Marquet, Pierre, Haufroid, Vincent, Elens, Laure
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462973/
https://ncbi.nlm.nih.gov/pubmed/28642710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00358
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