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MDM2/X Inhibitors as Radiosensitizers for Glioblastoma Targeted Therapy

Inhibition of the MDM2/X-p53 interaction is recognized as a potential anti-cancer strategy, including the treatment of glioblastoma (GB). In response to cellular stressors, such as DNA damage, the tumor suppression protein p53 is activated and responds by mediating cellular damage through DNA repair...

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Bibliografiske detaljer
Udgivet i:Front Oncol
Main Authors: Miles, Xanthene, Vandevoorde, Charlot, Hunter, Alistair, Bolcaen, Julie
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8296304/
https://ncbi.nlm.nih.gov/pubmed/34307171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.703442
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