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Highly Efficient and Tumor-Restricted Gene Transfer to Malignant Gliomas by Replication-Competent Retroviral Vectors

The first large randomized phase III trial in gene therapy demonstrated no improvement in the survival of patients injected with packaging cells that produced conventional replication-defective retroviral vectors carrying the herpes simplex virus thymidine kinase gene, a disappointing result that wa...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: WANG, WEI JUN, TAI, CHIEN-KUO, KASAHARA, NORIYUKI, CHEN, THOMAS C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295717/
https://ncbi.nlm.nih.gov/pubmed/12614563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/104303403321070810
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