Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy

Colorectal cancer (CRC) is multi-faceted with subtypes defined by genetic, histological, and immunologic features which are potentially influenced by inflammation, mutagens, and/or microbiota. CRCs with activating mutations in BRAF are associated with distinct clinical characteristics though the pat...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cancer Discov
Main Authors: DeStefano Shields, Christina E., White, James R., Chung, Liam, Wenzel, Alyssa, Hicks, Jessica L., Tam, Ada J., Chan, June L., Dejea, Christine M., Fan, Hongni, Michel, John, Maiuri, Ashley R., Sriramkumar, Shruthi, Podicheti, Ram, Rusch, Douglas B., Wang, Hao, De Marzo, Angelo M., Besharati, Sepideh, Anders, Robert A., Baylin, Stephen B., O’Hagan, Heather M., Housseau, Franck, Sears, Cynthia L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2021
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295175/
https://ncbi.nlm.nih.gov/pubmed/33632774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0770
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