PGD(2) and CRTH2 counteract Type 2 cytokine–elicited intestinal epithelial responses during helminth infection

Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth infection. How these epithelial responses are regulated remains incompletely understood. Here, we show that mice deficient in the prostaglandin...

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Udgivet i:J Exp Med
Main Authors: Oyesola, Oyebola O., Shanahan, Michael T., Kanke, Matt, Mooney, Bridget M., Webb, Lauren M., Smita, Shuchi, Matheson, Macy K., Campioli, Pamela, Pham, Duc, Früh, Simon P., McGinty, John W., Churchill, Madeline J., Cahoon, Jordan L., Sundaravaradan, Pavithra, Flitter, Becca A., Mouli, Karthik, Nadjsombati, Marija S., Kamynina, Elena, Peng, Seth A., Cubitt, Rebecca L., Gronert, Karsten, Lord, James D., Rauch, Isabella, von Moltke, Jakob, Sethupathy, Praveen, Tait Wojno, Elia D.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294949/
https://ncbi.nlm.nih.gov/pubmed/34283207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202178
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