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Structures of the human PGD(2) receptor CRTH2 reveal novel mechanisms for ligand recognition

The signaling of prostaglandin D(2) (PGD(2)) through a G protein-coupled receptor (GPCR), CRTH2, is a major pathway in type 2 inflammation. Compelling evidence suggests the therapeutic benefits of blocking CRTH2 signaling in many inflammatory disorders. Currently, a number of CRTH2 antagonists are u...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wang, Lei, Yao, Dandan, Deepak, R.N.V. Krishna, Liu, Heng, Xiao, Qingpin, Fan, Hao, Gong, Weimin, Wei, Zhiyi, Zhang, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223628/
https://ncbi.nlm.nih.gov/pubmed/30220562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.009
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