Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates Ir...

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Vydáno v:Sci Adv
Hlavní autoři: Laber, Samantha, Forcisi, Sara, Bentley, Liz, Petzold, Julia, Moritz, Franco, Smirnov, Kirill S., Al Sadat, Loubna, Williamson, Iain, Strobel, Sophie, Agnew, Thomas, Sengupta, Shahana, Nicol, Tom, Grallert, Harald, Heier, Margit, Honecker, Julius, Mianne, Joffrey, Teboul, Lydia, Dumbell, Rebecca, Long, Helen, Simon, Michelle, Lindgren, Cecilia, Bickmore, Wendy A., Hauner, Hans, Schmitt-Kopplin, Philippe, Claussnitzer, Melina, Cox, Roger D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294759/
https://ncbi.nlm.nih.gov/pubmed/34290091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0108
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