Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates Ir...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Laber, Samantha, Forcisi, Sara, Bentley, Liz, Petzold, Julia, Moritz, Franco, Smirnov, Kirill S., Al Sadat, Loubna, Williamson, Iain, Strobel, Sophie, Agnew, Thomas, Sengupta, Shahana, Nicol, Tom, Grallert, Harald, Heier, Margit, Honecker, Julius, Mianne, Joffrey, Teboul, Lydia, Dumbell, Rebecca, Long, Helen, Simon, Michelle, Lindgren, Cecilia, Bickmore, Wendy A., Hauner, Hans, Schmitt-Kopplin, Philippe, Claussnitzer, Melina, Cox, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294759/
https://ncbi.nlm.nih.gov/pubmed/34290091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0108
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