Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates Ir...

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書誌詳細
出版年:Sci Adv
主要な著者: Laber, Samantha, Forcisi, Sara, Bentley, Liz, Petzold, Julia, Moritz, Franco, Smirnov, Kirill S., Al Sadat, Loubna, Williamson, Iain, Strobel, Sophie, Agnew, Thomas, Sengupta, Shahana, Nicol, Tom, Grallert, Harald, Heier, Margit, Honecker, Julius, Mianne, Joffrey, Teboul, Lydia, Dumbell, Rebecca, Long, Helen, Simon, Michelle, Lindgren, Cecilia, Bickmore, Wendy A., Hauner, Hans, Schmitt-Kopplin, Philippe, Claussnitzer, Melina, Cox, Roger D.
フォーマット: Artigo
言語:Inglês
出版事項: American Association for the Advancement of Science 2021
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294759/
https://ncbi.nlm.nih.gov/pubmed/34290091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg0108
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