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On the stability and spectroscopic properties of 5-hydroxyoxazole-4-carboxylic acid derivatives

5-Hydroxyoxazole-4-carboxylic acid residues were advanced as substructures within the secondary bacterial metabolites precolibactins 969 and 795a. However, oxazoles containing both 5-hydroxy and 4-carboxy substituent are unprecedented. We have found these oxazoles are unstable toward hydrolytic ring...

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Detalles Bibliográficos
Publicado en:Org Lett
Main Authors: Tirla, Alina, Wernke, Kevin M., Herzon, Seth B.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294165/
https://ncbi.nlm.nih.gov/pubmed/34180681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.1c01796
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