GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic β-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux

T2DM (Type 2 diabetes) is a complex, chronic disease characterized as insulin resistance and islet β-cell dysfunction. Bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) surgery and laparoscopic sleeve gastrectomy (LSG) have become part of a critical treatment regimen in the treatment of ob...

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Detalles Bibliográficos
Publicado en:Front Cell Dev Biol
Main Authors: Li, Rao, Sun, Xulong, Li, Pengzhou, Li, Weizheng, Zhao, Lei, Zhu, Liyong, Zhu, Shaihong
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292745/
https://ncbi.nlm.nih.gov/pubmed/34307343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.646113
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