Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical. Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates to fill such a role, but their challenging synthesis limits...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Li, Chengxi, Callahan, Alex J., Simon, Mark D., Totaro, Kyle A., Mijalis, Alexander J., Phadke, Kruttika-Suhas, Zhang, Genwei, Hartrampf, Nina, Schissel, Carly K., Zhou, Ming, Zong, Hong, Hanson, Gunnar J., Loas, Andrei, Pohl, Nicola L. B., Verhoeven, David E., Pentelute, Bradley L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292409/
https://ncbi.nlm.nih.gov/pubmed/34285203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24598-4
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