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Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease

BACKGROUND: It is unknown whether liver sinusoidal endothelial cells (LSECs) metabolize alcohol. Chronic alcohol consumption decreases endothelial nitric oxide synthase (eNOS)-derived NO production typical of LSEC dysfunction. Heat shock protein 90 (Hsp90) interacts with eNOS to increase its activit...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Yang, Yilin, Sangwung, Panjamaporn, Kondo, Reiichiro, Jung, Yirang, McConnell, Matthew J., Jeong, Jain, Utsumi, Teruo, Sessa, William C., Iwakiri, Yasuko
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292196/
https://ncbi.nlm.nih.gov/pubmed/33675874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2021.02.028
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