Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis

BACKGROUND: Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here, we have mapped the spatial distribution of heterogeneous liver ECs in normal vs cirrhotic mouse livers and ide...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Su, Tingting, Yang, Yilin, Lai, Sanchuan, Jeong, Jain, Jung, Yirang, McConnell, Matthew, Utsumi, Teruo, Iwakiri, Yasuko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7903131/
https://ncbi.nlm.nih.gov/pubmed/33340713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.12.007
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