Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity

The maturation and functional competence of natural killer (NK) cells is a tightly controlled process that relies on transcription factors (TFs). Here, we identify transcriptional repressor zinc fingers and homeoboxes 2 (Zhx2) as a novel regulator that restricts NK cell maturation and function. Mice...

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Udgivet i:J Exp Med
Main Authors: Tan, Siyu, Guo, Xiaowei, Li, Mengzhen, Wang, Tixiao, Wang, Zehua, Li, Chunyang, Wu, Zhuanchang, Li, Nailin, Gao, Lifen, Liang, Xiaohong, Ma, Chunhong
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292132/
https://ncbi.nlm.nih.gov/pubmed/34279541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20210009
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