Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles

PURPOSE: We aimed to develop a nanocarrier formulation incorporating fenbendazole (FEN) and rapamycin (RAPA) with strong efficacy against A549 cancer cells. As FEN and RAPA are poorly soluble in water, it is difficult to apply them clinically in vivo. Therefore, we attempted to resolve this problem...

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Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Shin, Hee Ji, Jo, Min Jeong, Jin, Ik Sup, Park, Chun-Woong, Kim, Jin-Seok, Shin, Dae Hwan
Format: Artigo
Language:Inglês
Published: Dove 2021
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291852/
https://ncbi.nlm.nih.gov/pubmed/34295160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S315782
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