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Evaluation of the Physicochemical Properties, Pharmacokinetics, and In Vitro Anticancer Effects of Docetaxel and Osthol Encapsulated in Methoxy Poly(ethylene glycol)-b-Poly(caprolactone) Polymeric Micelles

Docetaxel (DTX), a taxane-based anticancer drug, and osthol (OTH), a coumarin-derivative compound, have shown anticancer effects against different types of cancers through various mechanisms. However, these drugs have low solubility in water and low oral bioavailability, and thus their clinical appl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Jo, Min Jeong, Lee, Yu Jin, Park, Chun-Woong, Chung, Youn Bok, Kim, Jin-Seok, Lee, Mi Kyeong, Shin, Dae Hwan
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794789/
https://ncbi.nlm.nih.gov/pubmed/33379376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010231
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